医学生物技术系张文个人简介
张文,女,湖南省祁阳县人,生物医学工程专业博士,副教授,硕士研究生导师。现为基础医学院医学生物技术系青年骨干教师。主讲课程为细胞生物学、医学免疫学。主要研究方向为:1.新型生物材料与组织工程;2.纳米材料在肿瘤免疫治疗中的应用。近年来以第一作者/通讯作者发表SCI文章十余篇,其中,发表在生物材料研究领域国际权威刊物Biomaterials上的学术论文为“ESI高被引论文”,引用次数达到700余次。担任广东省骨科材料与器械临床转化委员会青年分会委员,《Frontiers in Pharmacology》国际杂志民族药理学板块审稿编辑。
近年来主持课题:
1. 国家自然科学基金青年科学基金项目,一石二鸟:靶向Siglec-15的生物活性玻璃支架促进骨肿瘤的抑瘤重建,2021/1-2023/12,24万
2. 广东省自然科学基金面上项目,“一靶双向”生物活性玻璃支架的构建及其骨肉瘤术后治疗应用,2019/10-2022/09,10万
3. 中国博士后科学基金面上项目,具有骨修复和肿瘤消融双重功能的新型3D 打印支架的构建,2018/01-2020/01,5万
4. 华南师范大学青年教师培育基金,基于Sr-MNBG/BPQD的多功能骨修复支架的构建及其应用于骨肿瘤术后治疗的研究,2019/01-2020/12,3万
代表性论文:
1. Huang D, Wu T, Lan S, Liu C, Guo Z, Zhang W(通讯作者). In situ photothermal nano-vaccine based on tumor cell membrane-coated black phosphorus-Au for photo-immunotherapy of metastatic breast tumors. Biomaterials. 2022;(289):121808.(中科院1区TOP期刊,IF=15.304)
2. Zhang W, Guo Z, Huang D, Liu Z, Guo X, Zhong H. Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide. Biomaterials. 2011;(32):8555-61.(中科院1区TOP期刊,IF=10.317 ESI高被引)
3. Zhang W, Zhao F, Huang D, Fu X, Li X, Chen X. Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration. ACS Applied Materials & Interfaces. 2016;(8):30747-58. (中科院1区TOP期刊,IF=8.456)
4. Zhao H, Zhang W(共同第一作者), Liu Z, Huang D, Zhang W, Ye B, et al. Insights into the intracellular behaviors of black-phosphorus-based nanocomposites via surface-enhanced Raman spectroscopy. Nanophotonics. 2018;(7):1651-62. (中科院1区TOP期刊,IF=6.908)
5. Zhang W, Huang D, Zhao F, Gao W, Sun L, Li X, et al. Synergistic effect of strontium and silicon in strontium-substituted sub-micron bioactive glass for enhanced osteogenesis. Materials Science & Engineering C-Materials for Biological Applications. 2018;(89):245-55. (中科院1区,IF=5.88)
6. Huang D, Zhuang Z, Wang Z, Li S, Zhong H, Liu Z, Guo Z, Zhang W*(通讯作者). Black phosphorus-Au filter paper-based three-dimensional SERS substrate for rapid detection of foodborne bacteria. Applied Surface Science. 2019;(497):143825. (中科院1区TOP期刊,IF=6.188)
7. Huang Deqiu, Zhao Fujian, Gao Wendong, Chen Xiaofeng, Guo Zhouyi, Zhang Wen*(通讯作者). Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway. Regenerative Biomaterials. 2020; https://doi.org/10.1093/rb/rbaa004. (中科院1区,IF=4.188)